The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

The local microenvironment, or niche, of a cancer cell plays important roles in cancer
development. A major component of the niche is the extracellular matrix (ECM), a complex …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal
epithelial cells to the underlying basement membrane. The mechanical stability of …

For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

The skin constantly renews itself throughout adult life, and the hair follicle undergoes a
perpetual cycle of growth and degeneration. Stem cells (SCs) residing in the epidermis and …

Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …

Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness
program remains controversial. Here, we construct a gene module map to systematically …

Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-
dependent signaling. The downstream effectors of this pathway have not been previously …