Genome-wide association studies: theoretical and practical concerns

WYS Wang, BJ Barratt, DG Clayton… - Nature Reviews Genetics, 2005 - nature.com
To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …

Problems of reporting genetic associations with complex outcomes

HM Colhoun, PM McKeigue, GD Smith - The Lancet, 2003 - thelancet.com
Inability to replicate many results has led to increasing scepticism about the value of simple
association study designs for detection of genetic variants contributing to common complex …

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

H Ueda, JMM Howson, L Esposito, J Heward, Snook… - Nature, 2003 - nature.com
Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

The genetic association database

KG Becker, KC Barnes, TJ Bright, SA Wang - Nature genetics, 2004 - nature.com
The MMR system has evolved to increase the fidelity of DNA replication and homologous
recombination1. MMR is also implicated in the processing of other types of DNA damage, as …

Finding genes that underlie complex traits

AM Glazier, JH Nadeau, TJ Aitman - science, 2002 - science.org
Phenotypic variation among organisms is central to evolutionary adaptations underlying
natural and artificial selection, and also determines individual susceptibility to common …

Bayes factors for genome‐wide association studies: comparison with P‐values

J Wakefield - Genetic Epidemiology: The Official Publication of …, 2009 - Wiley Online Library
The Bayes factor is a summary measure that provides an alternative to the P‐value for the
ranking of associations, or the flagging of associations as “significant”. We describe an …

Publication bias in meta‐analyses from the Cochrane Database of Systematic Reviews

M Kicinski, DA Springate… - Statistics in medicine, 2015 - Wiley Online Library
We used a Bayesian hierarchical selection model to study publication bias in 1106 meta‐
analyses from the Cochrane Database of Systematic Reviews comparing treatment with …

Genetic association studies

HJ Cordell, DG Clayton - The Lancet, 2005 - thelancet.com
We review the rationale behind and discuss methods of design and analysis of genetic
association studies. There are similarities between genetic association studies and classic …

Association studies for finding cancer-susceptibility genetic variants

PDP Pharoah, AM Dunning, BAJ Ponder… - Nature Reviews …, 2004 - nature.com
Cancer is the result of complex interactions between inherited and environmental factors.
Known genes account for a small proportion of the heritability of cancer, and it is likely that …

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General …

D Smyth, JD Cooper, JE Collins, JM Heward… - Diabetes, 2004 - Am Diabetes Assoc
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true
positive irrefutable linkage and association results have been rare to date. Recently, it has …