Genome-wide association studies: theoretical and practical concerns
WYS Wang, BJ Barratt, DG Clayton… - Nature Reviews Genetics, 2005 - nature.com
To fully understand the allelic variation that underlies common diseases, complete genome
sequencing for many individuals with and without disease is required. This is still not …
sequencing for many individuals with and without disease is required. This is still not …
Problems of reporting genetic associations with complex outcomes
HM Colhoun, PM McKeigue, GD Smith - The Lancet, 2003 - thelancet.com
Inability to replicate many results has led to increasing scepticism about the value of simple
association study designs for detection of genetic variants contributing to common complex …
association study designs for detection of genetic variants contributing to common complex …
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda, JMM Howson, L Esposito, J Heward, Snook… - Nature, 2003 - nature.com
Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …
disorders that affect approximately 5% of the population, remain obscure. Here we identify …
The genetic association database
The MMR system has evolved to increase the fidelity of DNA replication and homologous
recombination1. MMR is also implicated in the processing of other types of DNA damage, as …
recombination1. MMR is also implicated in the processing of other types of DNA damage, as …
Finding genes that underlie complex traits
AM Glazier, JH Nadeau, TJ Aitman - science, 2002 - science.org
Phenotypic variation among organisms is central to evolutionary adaptations underlying
natural and artificial selection, and also determines individual susceptibility to common …
natural and artificial selection, and also determines individual susceptibility to common …
Bayes factors for genome‐wide association studies: comparison with P‐values
J Wakefield - Genetic Epidemiology: The Official Publication of …, 2009 - Wiley Online Library
The Bayes factor is a summary measure that provides an alternative to the P‐value for the
ranking of associations, or the flagging of associations as “significant”. We describe an …
ranking of associations, or the flagging of associations as “significant”. We describe an …
Publication bias in meta‐analyses from the Cochrane Database of Systematic Reviews
M Kicinski, DA Springate… - Statistics in medicine, 2015 - Wiley Online Library
We used a Bayesian hierarchical selection model to study publication bias in 1106 meta‐
analyses from the Cochrane Database of Systematic Reviews comparing treatment with …
analyses from the Cochrane Database of Systematic Reviews comparing treatment with …
Genetic association studies
HJ Cordell, DG Clayton - The Lancet, 2005 - thelancet.com
We review the rationale behind and discuss methods of design and analysis of genetic
association studies. There are similarities between genetic association studies and classic …
association studies. There are similarities between genetic association studies and classic …
Association studies for finding cancer-susceptibility genetic variants
Cancer is the result of complex interactions between inherited and environmental factors.
Known genes account for a small proportion of the heritability of cancer, and it is likely that …
Known genes account for a small proportion of the heritability of cancer, and it is likely that …
Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General …
D Smyth, JD Cooper, JE Collins, JM Heward… - Diabetes, 2004 - Am Diabetes Assoc
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true
positive irrefutable linkage and association results have been rare to date. Recently, it has …
positive irrefutable linkage and association results have been rare to date. Recently, it has …