Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose

Y Zhu, J Zhang, W Zhang, W Mu - Biotechnology Advances, 2023 - Elsevier
Human milk oligosaccharides (HMOs), the third major solid component in breast milk, are
recognized as the first prebiotics for health benefits in infants. Sialylated HMOs are an …

Review on the Impact of Milk Oligosaccharides on the Brain and Neurocognitive Development in Early Life

Y Fan, AL McMath, SM Donovan - Nutrients, 2023 - mdpi.com
Milk Oligosaccharides (MOS), a group of complex carbohydrates found in human and
bovine milk, have emerged as potential modulators of optimal brain development for early …

Exercise-induced 3′-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring

JE Harris, KM Pinckard, KR Wright, LA Baer, PJ Arts… - Nature …, 2020 - nature.com
Poor maternal environments, such as under-or overnutrition, can increase the risk for the
development of obesity, type 2 diabetes and cardiovascular disease in offspring …

Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations

RK Golden, LT Sutkus, LL Bauer, SM Donovan… - Frontiers in …, 2023 - frontiersin.org
Sialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-
SL), comprise a large portion of human milk and have been known to support development …

Preparation and synbiotic interaction mechanism of microcapsules of Bifidobacterium animalis F1–7 and human milk oligosaccharides (HMO)

X Huang, R Liu, J Wang, Y Bao, H Yi, X Wang… - International Journal of …, 2024 - Elsevier
Probiotics such as Bifidobacterium spp. generally possess important physiological functions.
However, maintaining probiotic viability is a challenge during processing, storage, and …

Early-life iron deficiency and subsequent repletion alters development of the colonic microbiota in the pig

LC Knight, M Wang, SM Donovan, RN Dilger - Frontiers in nutrition, 2019 - frontiersin.org
Background: Iron deficiency is the most prevalent micronutrient deficiency worldwide,
affecting over two billion people. Early-life iron deficiency may alter the developing …

[HTML][HTML] The Role of Milk Oligosaccharides in Enhancing Intestinal Microbiota, Intestinal Integrity, and Immune Function in Pigs: A Comparative Review

A Gormley, Y Garavito-Duarte, SW Kim - Biology, 2024 - mdpi.com
Simple Summary Young pigs face many challenges associated with weaning, including
disruption to a healthy and robust intestinal microbiota, leaving them vulnerable to infection …

Bovine milk oligosaccharides and human milk oligosaccharides modulate the gut microbiota composition and volatile fatty acid concentrations in a preclinical …

M Wang, MH Monaco, J Hauser, J Yan, RN Dilger… - Microorganisms, 2021 - mdpi.com
Milk oligosaccharides (OS) shape microbiome structure and function, but their relative
abundances differ between species. Herein, the impact of the human milk oligosaccharides …

Evaluation of 2'-Fucosyllactose and Bifidobacterium longum Subspecies infantis on Growth, Organ Weights, and Intestinal Development of Piglets

VC Daniels, MH Monaco, M Wang, J Hirvonen… - Nutrients, 2021 - mdpi.com
Human milk is rich in oligosaccharides that influence intestinal development and serve as
prebiotics for the infant gut microbiota. Probiotics and 2'-fucosyllactose (2'-FL) added …

[HTML][HTML] Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose protect intestine against necrotizing enterocolitis damage induced by hypoxia

Z Huang, Y Li, Y Luo, H Guo - Journal of Functional Foods, 2021 - Elsevier
In premature infants, necrotizing enterocolitis (NEC) is one of the most prevalent diseases
among premature infants and has a high mortality rate. Previous studies have shown that …