[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

Perilipins: a diversity of intracellular lipid droplet proteins

H Itabe, T Yamaguchi, S Nimura, N Sasabe - Lipids in health and disease, 2017 - Springer
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …

Targeting fat: mechanisms of protein localization to lipid droplets

N Kory, RV Farese, TC Walther - Trends in cell biology, 2016 - cell.com
How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …

[HTML][HTML] Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

R Liu, JH Lee, J Li, R Yu, L Tan, Y Xia, Y Zheng… - Molecular cell, 2021 - cell.com
Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …

Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1

CP Najt, SA Khan, TD Heden, BA Witthuhn, M Perez… - Molecular cell, 2020 - cell.com
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …

The perilipins: major cytosolic lipid droplet–associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis

AR Kimmel, C Sztalryd - Annual review of nutrition, 2016 - annualreviews.org
The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

Perilipins at a glance

CP Najt, M Devarajan, DG Mashek - Journal of cell science, 2022 - journals.biologists.com
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …

Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance

OR Brekk, JR Honey, S Lee… - Proceedings of the …, 2020 - National Acad Sciences
Neurons are dependent on proper trafficking of lipids to neighboring glia for lipid exchange
and disposal of potentially lipotoxic metabolites, producing distinct lipid distribution profiles …

Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1–3

ER Rowe, ML Mimmack, AD Barbosa, A Haider… - Journal of Biological …, 2016 - ASBMB
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on
the surface of lipid droplets. Failure of this activity results in severe metabolic disease in …