[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
Perilipins: a diversity of intracellular lipid droplet proteins
H Itabe, T Yamaguchi, S Nimura, N Sasabe - Lipids in health and disease, 2017 - Springer
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …
recognized as organelles with unique spherical structures. Although LDs are not stable lipid …
Targeting fat: mechanisms of protein localization to lipid droplets
How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …
[HTML][HTML] Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …
Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1
CP Najt, SA Khan, TD Heden, BA Witthuhn, M Perez… - Molecular cell, 2020 - cell.com
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …
fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and …
The perilipins: major cytosolic lipid droplet–associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis
AR Kimmel, C Sztalryd - Annual review of nutrition, 2016 - annualreviews.org
The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …
Perilipins at a glance
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …
Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance
OR Brekk, JR Honey, S Lee… - Proceedings of the …, 2020 - National Acad Sciences
Neurons are dependent on proper trafficking of lipids to neighboring glia for lipid exchange
and disposal of potentially lipotoxic metabolites, producing distinct lipid distribution profiles …
and disposal of potentially lipotoxic metabolites, producing distinct lipid distribution profiles …
Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1–3
ER Rowe, ML Mimmack, AD Barbosa, A Haider… - Journal of Biological …, 2016 - ASBMB
Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on
the surface of lipid droplets. Failure of this activity results in severe metabolic disease in …
the surface of lipid droplets. Failure of this activity results in severe metabolic disease in …