U1 snrnp‐dependent suppression of polyadenylation: Physiological role and therapeutic opportunities in cancer
L Spraggon, L Cartegni - International journal of cell biology, 2013 - Wiley Online Library
Pre‐mRNA splicing and polyadenylation are critical steps in the maturation of eukaryotic
mRNA. U1 snRNP is an essential component of the splicing machinery and participates in …
mRNA. U1 snRNP is an essential component of the splicing machinery and participates in …
Recent advances in polymeric nanosystems for treating cutaneous melanoma and its metastasis
YP Chou, YK Lin, CH Chen… - Current Pharmaceutical …, 2017 - ingentaconnect.com
Melanoma shows a high possibility of mortality after it metastasizes because of its
aggressive nature. Although there are several options for anti-melanoma therapy, this skin …
aggressive nature. Although there are several options for anti-melanoma therapy, this skin …
[HTML][HTML] The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma
RK Boregowda, DJ Medina, E Markert, MA Bryan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Receptor tyrosine kinases-based autocrine loops largely contribute to activate the MAPK
and PI3K/AKT pathways in melanoma. However, the molecular mechanisms involved in …
and PI3K/AKT pathways in melanoma. However, the molecular mechanisms involved in …
U1 interference (U1i) for antiviral approaches
L Blazquez, P Fortes - Gene therapy for HIV and chronic infections, 2015 - Springer
U1 snRNP (U1 small nuclear ribonucleoprotein) is an essential component of the splicing
machinery. U1 snRNP also plays an additional role in 3′-end mRNA processing when it …
machinery. U1 snRNP also plays an additional role in 3′-end mRNA processing when it …
U1 Adaptors Suppress the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts
AT Tsang, C Dudgeon, L Yi, X Yu, R Goraczniak… - Molecular cancer …, 2017 - AACR
Targeting KRAS and MYC has been a tremendous challenge in cancer drug development.
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
Comprehensive analysis of molecular mechanism and a novel prognostic signature based on small nuclear RNA biomarkers in gastric cancer patients
Z Liang, D Su, K Liu, H Jiang - Open Medicine, 2022 - degruyter.com
Small nuclear RNAs (snRNAs) are rarely reported in cancer. This study is based on The
Cancer Genome Atlas genome-wide data set to explore the prognostic value and molecular …
Cancer Genome Atlas genome-wide data set to explore the prognostic value and molecular …
Immunohistochemical features of partial regression in cutaneous melanoma–E-cadherin key molecule
C Dumitru, A Bastian, C Popp, M Neagu… - Human and …, 2017 - search.proquest.com
Background and objectives: Tumor regression in cutaneous melanoma remains a subject of
both intense studies and scientific contradictions. While some groups acknowledge it as a …
both intense studies and scientific contradictions. While some groups acknowledge it as a …
U1 adaptors suppress the KRAS-MYC oncogenic axis in human pancreatic cancer xenografts
SI Gunderson, MA Brenneman, S Kogan… - Molecular Cancer … - ldr.lafayette.edu
Targeting KRAS and MYC has been a tremendous challenge in cancer drug development.
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
[PDF][PDF] U1 Adaptors suppress the KRAS-MYC oncogenic axis in human pancreatic cancer xenografts
DRC EH - researchgate.net
Targeting KRAS and MYC has been a tremendous challenge in cancer drug development.
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
Genetic studies in mouse models have validated the efficacy of silencing expression of both …
[PDF][PDF] Mechanisms controlling mRNA processing and translation: decoding the regulatory layers defining gene expression through RNA sequencing
E Klerk - 2015 - scholarlypublications …
Poly (A) binding protein nuclear 1 (PABPN1) is a ubiquitous protein involved in
polyadenylation of premRNAs (1–4). An expansion mutation in the polyalanine repeat in the …
polyadenylation of premRNAs (1–4). An expansion mutation in the polyalanine repeat in the …