Comparative analysis of numerous protein structures that have become available in the past
few years, combined with genome comparison, has yielded new insights into the evolution …

We have developed tasser, a hierarchical approach to protein structure prediction that
consists of template identification by threading, followed by tertiary structure assembly via …

Bacteria can clearly enhance their survival by expanding their genetic repertoire. However,
the tight packing of the bacterial genome and the fact that the most evolved species do not …

Protein structural diversity encompasses a finite set of architectural designs. Embedded in
these topologies are evolutionary histories that we here uncover using cladistic principles …

The explosion in gene sequence data and technological breakthroughs in protein structure
determination inspired the launch of structural genomics (SG) initiatives. An often stated goal …

The Cas6 superfamily, the Cas5d subclass, and the host RNase III endoribonucleases are
responsible for producing small RNAs (crRNA) that function in the CRISPR-Cas immunity …

We present the structural annotation of 56 different bacterial species based on the
assignment of genes to 816 evolutionary superfamilies in the CATH domain structure …

Chalcone isomerase, an enzyme in the isoflavonoid pathway in plants, catalyzes the
cyclization of chalcone into (2S)‐naringenin. Chalcone isomerase sequence family and …

Phylogenetic profiling is a well established method for predicting functional relations and
physical interactions between proteins. We present a new method for finding such relations …

The Rossmann fold is one of the most commonly observed structural domains in proteins.
The fold is composed of consecutive alternating β-strands and α-helices that form a layer of …