Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by
expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome …

Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …

Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's …

Huntington's disease (HD) is a genetic neurodegenerative disease caused by abnormal
CAG expansion. MicroRNAs (miRNAs) are short RNA molecules regulating gene …

Post-translational modification by the lipid palmitate is crucial for the correct targeting and
function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at …

Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease
caused by an increase in the number of polyglutamine residues in the huntingtin (Htt) …

Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …