The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

Adolescence is a critical period of development. It is very likely that there is significant
maturation of the enteric nervous system (ENS) of the gut during this stage of life, especially …

The enteric nervous system (ENS) consists of thousands of small ganglia arranged in the
submucosal and myenteric plexuses, which can be negatively affected by Crohn's disease …

Inflammatory bowel diseases (IBDs) are chronic diseases of the gastrointestinal tract that
include ulcerative colitis and Crohn's disease and affect enteric neurons. Research has …

The digestive tracts of ulcerative colitis and Crohn's disease patients present with
pathophysiological processes and intestinal necrosis. This study examined the P2X7 …

The aim of this study was to evaluate the effect of ulcerative colitis on the submucosal
neurons and glial cells of the submucosal ganglia of rats. 2, 4, 6-Trinitrobenzene sulfonic …

We evaluated the chemical coding of the myenteric plexus in the proximal and distal
intestine of gilthead sea bream (Sparus aurata), which represents one of the most farmed …

Intestinal immunity is finely regulated by several concomitant and overlapping mechanisms,
in order to efficiently sense external stimuli and mount an adequate response of either …