In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

Members of the transforming growth factor-β (TGF-β) family have important roles during
embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their …

The mobilization of metabolic energy from adipocytes depends on a tightly regulated
balance between hydrolysis and resynthesis of triacylglycerides (TAGs). Hydrolysis is …

The phenotypic switch underlying the differentiation of cardiac fibroblasts into
hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial …

Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers
patients has continued at a feverish pace following exciting developments linking energy …

IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The
mechanisms underlying these processes are not known. We report that IL11-stimulated …

It is increasingly evident that cancer results from altered organ homeostasis rather than from
deregulated control of single cells or groups of cells. This applies especially to epithelial …

Regulatory T (Treg) cells are a distinct T-cell lineage characterized by sustained Foxp3
expression and potent suppressor function, but the upstream dominant factors that preserve …

Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to
gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse …

Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical
cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated …