Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs
P Tran, YC Pyo, DH Kim, SE Lee, JK Kim, JS Park - Pharmaceutics, 2019 - mdpi.com
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …
Investigation into the solid-state properties and dissolution profile of spray-dried ternary amorphous solid dispersions: a rational step toward the design and …
S Baghel, H Cathcart, NJ O'Reilly - Molecular pharmaceutics, 2018 - ACS Publications
The formulation of oral amorphous solid dispersions (ASD) includes the use of excipients to
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …
Effect of GA3, KNO3, and removing of basal point of seeds on germination of sweet granadilla (Passiflora ligularis Juss) and yellow passion fruit (Passiflora edulis f …
Passiflora seeds germinate erratically presenting difficulties for their handling in a
greenhouse. The effect of removing of basal point of seeds (RB) and pre-imbibition of seeds …
greenhouse. The effect of removing of basal point of seeds (RB) and pre-imbibition of seeds …
Solid dispersions of atorvastatin with Kolliphor RH40: Enhanced supersaturation and improvement in a hyperlipidemic rat model
C Torrado-Salmerón, V Guarnizo-Herrero… - International Journal of …, 2023 - Elsevier
Atorvastatin is a potent lipid-lowering drug with poor solubility and high presystemic
clearance that limits its therapeutic efficacy. The aim of this study was to develop solid …
clearance that limits its therapeutic efficacy. The aim of this study was to develop solid …