As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Obesity and its comorbidities, including type 2 diabetes and cardiovascular disease, are
straining our healthcare system, necessitating the development of novel strategies for weight …

The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs
in response to infection with DNA viruses and to presence of host DNA in the cytosol …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

Numerous electrophilic metabolites are formed during cellular activity, particularly under
conditions of oxidative, inflammatory and metabolic stress. Among them are lipid oxidation …

Polyunsaturated fatty acids (PUFA) are fundamental building materials for cells and play
crucial function as signaling molecules. When PUFA are used as substrates for non …

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may
increase the risk of fatty liver disease and other metabolic disorders. To identify potential …

Objective—Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by
producing paracrine factors. Previously, we reported that selective deletion of PPARγ …

Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-
inflammatory actions in experimental mouse models of autoimmune and allergic diseases …

Lower circulating levels of glycine are consistently reported in association with
cardiovascular disease (CVD), but the causative role and therapeutic potential of glycine in …