Long chain fatty acids as modulators of immune cells function: contribution of FFA1 and FFA4 receptors

MA Hidalgo, MD Carretta, RA Burgos - Frontiers in Physiology, 2021 - frontiersin.org
Long-chain fatty acids are molecules that act as metabolic intermediates and constituents of
membranes; however, their novel role as signaling molecules in immune function has also …

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review

Y Liu, J Wang, S Luo, Y Zhan, Q Lu - Journal of Autoimmunity, 2020 - Elsevier
Autoimmune diseases are common diseases of the immune system that are characterized
by the loss of self-tolerance and the production of autoantibodies; the breakdown of immune …

[HTML][HTML] Loss of EMP1 promotes the metastasis of human bladder cancer cells by promoting migration and conferring resistance to ferroptosis through activation of …

S Liu, J Shi, L Wang, Y Huang, B Zhao, H Ding… - Free Radical Biology …, 2022 - Elsevier
Metastasis, in which cancer cells detach from the original site and colonise other organs, is
the primary cause of death induced by bladder cancer (BCa). Epithelial Membrane Protein 1 …

FABP4 in macrophages facilitates obesity-associated pancreatic cancer progression via the NLRP3/IL-1β axis

J Yang, S Liu, Y Li, Z Fan, Y Meng, B Zhou, G Zhang… - Cancer Letters, 2023 - Elsevier
Obesity is an essential risk factor for pancreatic cancer (PC). Macrophage-induced
inflammation plays a pivotal role in obesity-associated carcinogenesis and disease …

Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity

AK Fleck, S Hucke, F Teipel, M Eschborn, C Janoschka… - Brain, 2021 - academic.oup.com
A close interaction between gut immune responses and distant organ-specific autoimmunity
including the CNS in multiple sclerosis has been established in recent years. This so-called …

Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary

DD Meling, M Kathy, AS Arango, A Gonsioroski… - Reproductive …, 2022 - Elsevier
Widespread use of phthalates as solvents and plasticizers leads to everyday human
exposure. The mechanisms by which phthalate metabolites act as ovarian toxicants are not …

Nutrient sensors and their crosstalk

Y Sung, YC Yu, JM Han - Experimental & Molecular Medicine, 2023 - nature.com
The macronutrients glucose, lipids, and amino acids are the major components that maintain
life. The ability of cells to sense and respond to fluctuations in these nutrients is a crucial …

The emerging therapeutic potential of nitro fatty acids and other Michael acceptor-containing drugs for the treatment of inflammation and cancer

M Piesche, J Roos, B Kühn, J Fettel… - Frontiers in …, 2020 - frontiersin.org
Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions
of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore …

Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling

M Zhang, L Hou, W Tang, W Lei, H Lin… - Journal of Cellular …, 2023 - Wiley Online Library
Both lipid accumulation and inflammatory response in lesion macrophages fuel the
progression of atherosclerosis, leading to high mortality of cardiovascular disease. A …

Regulation of arachidonic acid oxidation and metabolism by lipid electrophiles

A Trostchansky, I Wood, H Rubbo - Prostaglandins & Other Lipid Mediators, 2021 - Elsevier
Arachidonic acid (AA) is a precursor of enzymatic and non-enzymatic oxidized products
such as prostaglandins, thromboxanes, leukotrienes, lipoxins, and isoprostanes. These …