Magnetic nanoparticles: current advances in nanomedicine, drug delivery and MRI
C Comanescu - Chemistry, 2022 - mdpi.com
Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due
to the rapid expansion of nanotechnology and to their active magnetic core with a high …
to the rapid expansion of nanotechnology and to their active magnetic core with a high …
Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine …
AA Mandour, IF Nassar, MT Abdel Aal… - Journal of enzyme …, 2022 - Taylor & Francis
Cyclin-dependent kinase inhibition is considered a promising target for cancer treatment for
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
its crucial role in cell cycle regulation. Pyrazolo pyrimidine derivatives were well established …
Green Design, Synthesis, and Molecular Docking Study of Novel Quinoxaline Derivatives with Insecticidal Potential against Aphis craccivora
An efficient and environmentally friendly method was established for designing novel 3-
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …
Pyrazolo [3, 4-d] pyrimidine derivatives as EGFRT790M and VEGFR-2 dual TK inhibitors: Design, synthesis, molecular docking, ADMET profile and anticancer …
Abstract Seventeen new pyrazolo [3, 4-d] pyrimidine derivatives have been designed,
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …
Novel 6, 7, 8-trihydrobenzo [6', 7'] cyclohepta [2', 1'-e] pyrazolo [2, 3-a] pyrimidine derivatives as Topo IIα inhibitors with potential cytotoxic activity
TA Farghaly, HG Abdulwahab, HY Medrasi… - Bioorganic …, 2022 - Elsevier
Abstract Novel tetracyclic pyrazolo [1, 5-a] pyrimidine derivatives; namely benzo [3, 4]
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
cyclohepta [1, 2-e] pyrazolo [1, 5-a] pyrimidin-2-amines 6a-e and benzo [3, 4] cyclohepta [1 …
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by …
AKB Aljohani, WAZ El Zaloa, M Alswah… - International journal of …, 2023 - mdpi.com
Phenylpyrazolo [3, 4-d] pyrimidine is considered a milestone scaffold known to possess
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
various biological activities such as antiparasitic, antifungal, antimicrobial, and …
Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells
DJ Baillache, T Valero, Á Lorente-Macías… - RSC Medicinal …, 2023 - pubs.rsc.org
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer in adults, with an
average life expectancy under treatment of approx. 15 months. GBM is characterised by a …
average life expectancy under treatment of approx. 15 months. GBM is characterised by a …
Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6, 7, 8, 9-tetrahydropyrazolo [3, 4-d] pyrido [1, 2-a] pyrimidin-4 (1H)-one as DDR2 kinase inhibitor: Synthesis …
Z Ruzi, K Bozorov, L Nie, J Zhao, HA Aisa - Bioorganic Chemistry, 2023 - Elsevier
We report the synthesis, molecular docking and anticancer properties of the novel
compound (E)-1-methyl-9-(3-methylbenzylidene)-6, 7, 8, 9-tetrahydropyrazolo [3, 4-d] pyrido …
compound (E)-1-methyl-9-(3-methylbenzylidene)-6, 7, 8, 9-tetrahydropyrazolo [3, 4-d] pyrido …
Revisiting Structure-activity Relationships: Unleashing the potential of selective Janus kinase 1 inhibitors
M Shan, X Zhao, P Sun, X Qu, G Cheng, LP Qin - Bioorganic Chemistry, 2024 - Elsevier
Janus kinases (JAKs), a kind of non-receptor tyrosine kinases, the function has been
implicated in the regulation of cell proliferation, differentiation and apoptosis, immune …
implicated in the regulation of cell proliferation, differentiation and apoptosis, immune …