Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

Vertebrate genomes exhibit marked CG suppression—that is, lower than expected numbers
of 5′-CG-3′ dinucleotides. This feature is likely to be due to C-to-T mutations that have …

Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …

SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to
repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the …

ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers
of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …

NAD+, as an emerging regulator of immune responses during viral infections, may be a
promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …