The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
N Kumar, S Raja, B Van Houten - Nucleic acids research, 2020 - academic.oup.com
The six major mammalian DNA repair pathways were discovered as independent
processes, each dedicated to remove specific types of lesions, but the past two decades …
processes, each dedicated to remove specific types of lesions, but the past two decades …
Recent advances in the structural mechanisms of DNA glycosylases
SC Brooks, S Adhikary, EH Rubinson… - Biochimica et Biophysica …, 2013 - Elsevier
DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
H Hashimoto, S Hong, AS Bhagwat… - Nucleic acids …, 2012 - academic.oup.com
The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation
via the base excision repair pathway. TDG excises the mismatched base from G: X …
via the base excision repair pathway. TDG excises the mismatched base from G: X …
Role of base excision “repair” enzymes in erasing epigenetic marks from DNA
AC Drohat, CT Coey - Chemical reviews, 2016 - ACS Publications
Base excision repair (BER) is one of several DNA repair pathways found in all three
domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs …
domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs …
MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles
AB Sjolund, AG Senejani, JB Sweasy - Mutation Research/Fundamental …, 2013 - Elsevier
The base excision repair system is vital to the repair of endogenous and exogenous DNA
damage. This pathway is initiated by one of several DNA glycosylases that recognizes and …
damage. This pathway is initiated by one of several DNA glycosylases that recognizes and …
Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites
A Bellacosa, AC Drohat - DNA repair, 2015 - Elsevier
Cytosine methylation at CpG dinucleotides is a central component of epigenetic regulation
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …
Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to …
CR Quilter, WN Cooper, KM Cliffe… - The FASEB …, 2014 - Wiley Online Library
Size at birth, postnatal weight gain, and adult risk for type 2 diabetes may reflect
environmental exposures during developmental plasticity and may be mediated by …
environmental exposures during developmental plasticity and may be mediated by …
Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA
A Maiti, AZ Michelson, CJ Armwood… - Journal of the …, 2013 - ACS Publications
5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …
Differential stabilities and sequence-dependent base pair opening dynamics of Watson–Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5 …
5-Hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC)
form during active demethylation of 5-methylcytosine (5mC) and are implicated in epigenetic …
form during active demethylation of 5-methylcytosine (5mC) and are implicated in epigenetic …
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
CT Coey, SS Malik, LS Pidugu, KM Varney… - Nucleic acids …, 2016 - academic.oup.com
Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …