Patients with chronic kidney disease (CKD) are frequently afflicted with neurological
complications. These complications can potentially affect both the central and peripheral …

Adverse drug reactions (ADRs) are an important and frequent cause of morbidity and
mortality. ADR can be related to a variety of drugs, including anticonvulsants, anaesthetics …

The publication of the Australasian Creatinine Consensus Working Group's position
statements in 2005 and 2007 resulted in automatic reporting of estimated glomerular …

Background Chronic kidney disease (CKD) afflicts many older adults and increases the risk
for medication-related adverse events. Objective The aim of this study was to assess the …

Simple Summary Adjusting drug dosages in dogs and cats with chronic kidney disease
(CKD) can be challenging in clinical practice due to the lack of specific indications in the …

Individualized therapy with pharmaceutical products aims to elicit predictable and optimized
treatment responses from specific patients. Doing so requires production platforms and …

We aimed at reviewing age-related changes in kidney structure and function, methods for
estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as …

Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for
the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate …

Prediction of pharmacokinetic profiles of new chemical entities is essential in drug
development to minimize the risks of potential withdrawals. The excretion of unchanged …

In order to adjust the dose of renally excreted drugs in response to reduced renal function, it
is necessary to make a quantitative estimate of the glomerular filtration rate (GFR) of the …