Improved understanding of the pathogenesis of acute lung injury (ALI)/ARDS has led to
important advances in the treatment of ALI/ARDS, particularly in the area of ventilator …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) 13 occur in diseases
such as sepsis and severe pneumonia49, 69 that cause diffuse inflammation in the …

Background We tested the hypothesis that the pressure-time (Pt) curve during constant flow
ventilation can be used to set a noninjurious ventilatory strategy. Methods In an isolated …

The term permissive hypercapnia defines a ventilatory strategy for acute respiratory failure in
which the lungs are ventilated with a low inspiratory volume and pressure. The aim of …

In mechanically ventilated neonates, the instrumental dead space is a major determinant of
total minute ventilation. By flushing this dead space, continuous tracheal gas insufflation …

Background Pressure control ventilation (PCV), high-frequency oscillation (HFO), and
intratracheal pulmonary ventilation (ITPV) may all be used to provide lung protective …

Over the past 50 years, a variety of techniques have been developed that have in common
the insufflation of gas into the central airway to facilitate carbon dioxide (CO2) clearance …

To examine the hypothesis that combined treatment with tracheal gas insufflation (TGI) and
partial liquid ventilation (PLV) may improve pulmonary outcome relative to either treatment …

Although tracheal gas insufflation (TGI) has proved to be a useful adjunct to mechanical
ventilation, end-inspiratory as well as end-expiratory pressures may increase. We …

Objective The major benefit of tracheal gas insufflation (TGI) is an increase in CO 2
elimination efficiency by removal of CO 2 from the anatomical deadspace. In conjunction …