Abstract l-lactate formation occurs via the reduction of pyruvate catalyzed by lactate
dehydrogenase. l-lactate removal takes place via its oxidation into pyruvate, which may be …

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the
role of coding variation on these traits by analysis of variants on the HumanExome …

Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by
elevated blood glucose. Multiple environmental and genetic factors can increase the risk of …

Objective The aim of this study was to investigate the association of risk variants for type 2
diabetes (T2D) and hyperglycemia with gestational diabetes (GDM). Design and methods …

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have
identified common variant signals which explain 4.8% and 1.2% of trait variance …

Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic
variation underlying human traits. Here we apply genotype imputation based on whole …

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit, primarily expressed
in pancreatic islet β cells, which modulates the sensitivity of insulin secretion to glucose and …

Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level
and generates a striking expansion of coding capacities of genomes and cellular protein …

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the
sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG) …

Elevated fasting blood glucose (FBG) is associated with increased risks of developing type 2
diabetes (T2D) and cardiovascular-associated mortality. G6PC2 is predominantly expressed …