For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …

Depressive disorder is one of the most widespread forms of psychiatric pathology,
worldwide. According to a report by the World Health Organization, the number of people …

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces
sleep. Such sleep could enable resilience, but how stress promotes sleep is unclear. Activity …

When an animal faces a threatening situation while asleep, rapid arousal is the essential
prerequisite for an adequate response. Here, we find that predator stimuli induce immediate …

Among the central goals of stress neurobiology research is to understand the mechanisms
by which stressors change neural circuit function to precipitate or exacerbate psychiatric …

The uncertain, ever-changing and an ongoing nature of the COVID-19 pandemic means that
it may take some time before we can fully appreciate the negative effect of the pandemic and …

Rapid eye movement (REM) sleep is an enigmatic and intriguing sleep state. REM sleep
differs from non-REM sleep by its characteristic brain activity and from wakefulness by a …

Introduction Depression, the most prevalent mood disorder, has high comorbidity with
cerebrovascular disease and cognitive decline. However, there is little understanding of the …

Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened
latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram …

Stressful experiences are part of everyday life and animals have evolved physiological and
behavioral responses aimed at coping with stress and maintaining homeostasis. However …