Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

Poor water solubility and poor bioavailability are problems with many pharmaceuticals.
Increasing surface area by micronization is an effective strategy to overcome these …

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Objectives Recently, co-amorphous drug–amino acid mixtures were introduced as a
promising alternative to other amorphous stabilization approaches such as the use of …

Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to
their dissolution rate inadequate to treat the pathology of interest. A large drug particle size …

Nanostructured materials have been attracting increased attention for a wide variety of
applications due to their superior properties compared to their bulk counterparts. Current …

A new approach for enhancing the dispersibility of respirable powders containing poorly
soluble pharmaceutical actives is demonstrated. Budesonide was spray-dried with leucine …

Poor aqueous solubility of drug candidates is a major challenge for the pharmaceutical
scientists involved in drug development. Particle size reduction appears as an effective and …