Toxic mechanisms of cadmium and exposure as a risk factor for oral and gastrointestinal carcinomas

A Tavakoli Pirzaman, P Ebrahimi… - Human & …, 2023 - journals.sagepub.com
Incidence and mortality rates of gastrointestinal (GI) and oral cancers are among the highest
in the world, compared to other cancers. GI cancers include esophageal, gastric, colon …

[HTML][HTML] Breast cancer animal models and applications

L Zeng, W Li, CS Chen - Zoological research, 2020 - ncbi.nlm.nih.gov
Breast cancer is the most common malignancy in women. Basic and translational breast
cancer research relies heavily on experimental animal models. Ideally, such models for …

[HTML][HTML] Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells

GK Subbaraj, T Masoodi, SK Yasam… - Biomedicine & …, 2023 - Elsevier
The present study evaluated the efficacy of nano-formulated water-soluble kaempferol and
combretastatin alone and combined against the native kaempferol and combretastatin on …

[HTML][HTML] Dose dependent effects of cadmium on tumor angiogenesis

T Wei, J Jia, Y Wada, CM Kapron, J Liu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Angiogenesis is crucial for tumor growth and metastasis. Cadmium (Cd) exposure is
associated with elevated cancer risk and mortality. Such association is, at least in part …

Ang-1 and VEGF: central regulators of angiogenesis

Y Zhao, B Yu, Y Wang, S Tan, Q Xu, Z Wang… - Molecular and Cellular …, 2024 - Springer
Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …

Endothelial cell response to Fusobacterium nucleatum

RT Mendes, D Nguyen, D Stephens… - Infection and …, 2016 - Am Soc Microbiol
Vascular response is an essential aspect of an effective immune response to periodontal
disease pathogens, as new blood vessel formation contributes to wound healing and …

Y-27632 impairs angiogenesis on extra-embryonic vasculature in post-gastrulation chick embryos

JW Duess, JH Gosemann, A Kaskova Gheorghescu… - Toxics, 2023 - mdpi.com
Y-27632 inhibits Rho-associated coiled-coil-containing protein kinase (ROCK) signaling,
which is involved in various embryonic developmental processes, including angiogenesis …

[HTML][HTML] Embryonic toxico-pathological effects of meglumine antimoniate using a chick embryo model

A Khosravi, I Sharifi, H Tavakkoli, A Derakhshanfar… - PLoS …, 2018 - journals.plos.org
Leishmaniasis is one of the diverse and neglected tropical diseases. Embryo-toxicity of
drugs has always been a major concern. Chick embryo is a preclinical model relevant in the …

Fibroblast activation protein-α in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways

F Cao, S Wang, H Wang… - Molecular medicine …, 2018 - spandidos-publications.com
Fibroblast activation protein-α (FAP-α) is a cell surface serine protease of the post-prolyl
peptidase family, and stromal FAP-α expression may serve important functions in tumor …

DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium

X Bian, Y Gao - Environmental Science and Pollution Research, 2021 - Springer
An unexplored attributing molecular mechanism of Cd toxicity is interference with the
epigenetic machinery, such as DNA methylation, processes that are crucial for early fetal …