Abstract Background GC-Biased Gene Conversion (gBGC) is one of the important theories
put forward to explain profound long-range non-randomness in nucleotide compositions …

Two factors are thought to have contributed to the origin of codon usage bias in eukaryotes:
1) genome-wide mutational forces that shape overall GC-content and create context …

Mammalian genomes are replete with millions of polymorphic sites, among which those
genetic variants that are colocated on the same chromosome and exist close to one another …

Background Population genetic analyses based on genome-wide sequencing data have
been carried out for Sinorhizobium medicae and S. meliloti, two closely related bacterial …

Multicellular eukaryotic genomes are replete with nonprotein coding sequences, both within
genes (introns) and between them (intergenic regions). Excluding the well‐recognized …

We examined seventy million well-characterized human mutations, and their impact on G+ C-
compositional dynamics, in order to understand the formation and maintenance of major …

Genomic patterns on short-range scales represent various “words” composed from
nucleotide “letters.” Each of these words occurs many times within DNA sequences. The …

Markov models have been an indisputably useful tool in the field of bioinformatics. In the
current study we extend and complement existing Markov model algorithms by developing …

In order to investigate the complexity of mutations, a computational approach named
Genome Evolution by Matrix Algorithms (GEMA) has been implemented. GEMA models …

The fields of population genetics, evolutionary computing, and artificial life have existed as
separate domains for a number of decades. Here, I present an ambitious model of the …