Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer
R Stading, G Gastelum, C Chu, W Jiang… - Seminars in cancer …, 2021 - Elsevier
Lung cancer has the second highest incidence and highest mortality compared to all other
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …
cancers. Polycyclic aromatic hydrocarbon (PAH) molecules belong to a class of compounds …
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes
YJ Kwon, S Shin, YJ Chun - Archives of pharmacal research, 2021 - Springer
Human cytochrome P450 enzymes (CYPs) play a critical role in various biological
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
MOF-74/polystyrene-derived Ni-doped hierarchical porous carbon for structure-oriented extraction of polycyclic aromatic hydrocarbons and their metabolites from …
Y Shi, J Huang, L Chen, S Wang, J Xu, F Zhu… - Journal of Hazardous …, 2022 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs), as a major source that significantly increase the
risk of developing lung cancer, severely jeopardize public health in modern society. The …
risk of developing lung cancer, severely jeopardize public health in modern society. The …
PM2. 5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis
S Li, L Li, C Zhang, H Fu, S Yu, M Zhou, J Guo, Z Fang… - Elife, 2023 - elifesciences.org
Epidemiological studies have demonstrated that fine particulate matter (PM2. 5) is
associated with adverse obstetric and postnatal metabolic health outcomes, but the …
associated with adverse obstetric and postnatal metabolic health outcomes, but the …
Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells
CH Chang, YT Lien, WS Lin… - Journal of agricultural …, 2023 - ACS Publications
Evidence shows that the dietary intake of polycyclic aromatic hydrocarbons (PAHs) from
food processing induces the cellular DNA damage response and leads to the development …
food processing induces the cellular DNA damage response and leads to the development …
Genotoxic effects of marine pollutants on coastal meso-zooplankton populations–A mini-review
S Thirunavukkarasu, JS Hwang - Marine Pollution Bulletin, 2024 - Elsevier
Meso-zooplankton plays a vital role in maintaining healthy marine ecosystems, and some of
the taxa provide biological indications for the monitoring of environmental and climate …
the taxa provide biological indications for the monitoring of environmental and climate …
Metabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury
S Chen, M Zhou, X Zhao, Y Han, Y Huang… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Keguan-1 (KG-1) plays a vital role in enhancing the curative effects,
improving quality of life, and reducing the development of acute lung injury (ALI). Objective …
improving quality of life, and reducing the development of acute lung injury (ALI). Objective …
Mutagenicity risk prediction of PAH and derivative mixtures by in silico simulations oriented from CYP compound I-mediated metabolic activation
C Chen, Y Min, X Li, D Chen, J Shen, D Zhang… - Science of the total …, 2021 - Elsevier
PAHs and their derivatives are the main sources of mutagenicity and carcinogenicity in
airborne particular matter and cause serious public health and environmental problems …
airborne particular matter and cause serious public health and environmental problems …
Establishment of cytochrome P450 1a gene-knockout Javanese medaka, Oryzias javanicus, which distinguishes toxicity modes of the polycyclic aromatic …
Abstract Cytochrome P450 1a (Cyp1a) is an important enzyme for metabolism of organic
pollutants. To understand its reaction to polycyclic aromatic hydrocarbons (PAHs), we …
pollutants. To understand its reaction to polycyclic aromatic hydrocarbons (PAHs), we …
Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP) 1B1 by Dietary Antioxidants, Omega-3 Fatty …
G Zhou, W Jiang, G Xia, L Wang, M Richardson, C Chu… - Antioxidants, 2022 - mdpi.com
Numerous human and animal studies have reported positive correlation between
carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA …
carcinogen-DNA adduct levels and cancer occurrence. Therefore, attenuation of DNA …