Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Melatonin, the major hormone produced by the pineal gland, displays characteristic daily
and seasonal patterns of secretion. These robust and predictable rhythms in circulating …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

The pineal product melatonin has remarkable antioxidant properties. It is secreted during
darkness and plays a key role in various physiological responses including regulation of …

Benzodiazepine sedative‐hypnotic drugs are widely used for the treatment of insomnia.
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …

Agomelatine (S20098) displayed p K i values of 6.4 and 6.2 at native (porcine) and cloned,
human (h) 5-hydroxytryptamine (5-HT) 2C receptors, respectively. It also interacted with h5 …

Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …