Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification
Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y Xie - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
A Hammuda, R Shalaby, S Rovida… - European journal of …, 2016 - Elsevier
A novel series of substituted chalcones were designed and synthesized to be evaluated as
selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl …
selective human MAO-B inhibitors. A combination of either methylsulfonyl or trifluoromethyl …
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors
JW Choi, BK Jang, N Cho, JH Park, SK Yeon… - Bioorganic & Medicinal …, 2015 - Elsevier
We have synthesized three categories of α, β-unsaturated carbonyl derivatives and
evaluated their MAO-A and MAO-B inhibitory activities. Among them, compound 10b …
evaluated their MAO-A and MAO-B inhibitory activities. Among them, compound 10b …
Development of fluorinated methoxylated chalcones as selective monoamine oxidase-B inhibitors: Synthesis, biochemistry and molecular docking studies
A series of methoxylated chalcones with fluoro and trifluoromethyl derivatives were
synthesized and investigated for their ability to inhibit human monoamine oxidase A and B …
synthesized and investigated for their ability to inhibit human monoamine oxidase A and B …
Synthesis and biological evaluation of substituted aurone derivatives as potential tyrosinase inhibitors: in vitro, kinetic, QSAR, docking and drug-likeness studies
Tyrosinase enzyme plays an essential role in melanin biosynthesis and enzymatic browning
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
of fruits and vegetables. To discover potent tyrosinase inhibitors, the present studies were …
Synthesis, biochemistry, and computational studies of brominated thienyl chalcones: A new class of reversible MAO‐B inhibitors
Abstract A series of (2E)‐1‐(5‐bromothiophen‐2‐yl)‐3‐(para‐substituted phenyl) prop‐2‐en‐
1‐ones (TB1–TB11) was synthesized and tested for inhibitory activity toward human …
1‐ones (TB1–TB11) was synthesized and tested for inhibitory activity toward human …
Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors
Chalcone has been reported to be a valid scaffold for the design of monoamine oxidase
(MAO) inhibitors. This scenario has amplified the momentum for the discovery of heteroaryl …
(MAO) inhibitors. This scenario has amplified the momentum for the discovery of heteroaryl …
Piperazine-substituted chalcones: A new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
Abstract Eleven piperazine-containing 1, 3-diphenylprop-2-en-1-one derivatives (PC1-
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
Novel class of chalcone oxime ethers as potent monoamine oxidase-B and acetylcholinesterase inhibitors
JM Oh, TM Rangarajan, R Chaudhary, RP Singh… - Molecules, 2020 - mdpi.com
Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory
activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty …
activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Twenty …