Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby
keep both the genome and the transcriptome under extensive surveillance. Recent progress …

Adult tissue-specific stem cells have the capacity to self-renew and generate functional
differentiated cells that replenish lost cells throughout an organism's lifetime. Studies on …

Increasingly complex networks of small RNAs act through RNA-interference (RNAi)
pathways to regulate gene expression, to mediate antiviral responses, to organize …

In Drosophila, Piwi (P-element-induced wimpy testis), which encodes a protein of the
Argonaute family, is essential for germ stem cell self-renewal. Piwi has recently been shown …

The evolutionarily conserved Argonaute/PIWI (AGO/PIWI, also known as PAZ-PIWI domain
or PPD) family of proteins is crucial for the biogenesis and function of small noncoding RNAs …

ABSTRACT PIWI proteins and Piwi-interacting RNAs (piRNAs) have established and
conserved roles in repressing transposable elements (TEs) in the germline of animals …

Despite the large evolutionary distance between the plant and animal kingdoms, stem cells
in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell …

The maintenance of stem cells in defined locations is crucial for all multicellular organisms.
Although intrinsic factors and signals for stem cell fate have been identified in several …

Genome-wide identification of RNAs associated with RNA-binding proteins is crucial for
deciphering posttranscriptional regulatory systems. PUMILIO is a member of the …

Genetic studies have shown that Aubergine (Aub), one of the Piwi subfamily of Argonautes
in Drosophila, is essential for germ cell formation and maintaining fertility. aub mutations …