Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

M Ashrafizadeh, CD Mohan… - Medicinal research …, 2023 - Wiley Online Library
Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

H Lin, J Zhou, T Ding, Y Zhu, L Wang, T Zhong… - European Journal of …, 2024 - Springer
Cancer, a prevalent and complex disease, presents a significant challenge to the medical
community. It is characterized by irregular cell differentiation, excessive proliferation …

[HTML][HTML] Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress

X Qin, K Zhang, J Qiu, N Wang, K Qu, Y Cui, J Huang… - Bioactive Materials, 2022 - Elsevier
Extracellular vesicles (EVs) are increasingly used as delivery vehicles for drugs and
bioactive molecules, which usually require intravascular administration. The endothelial …

MicroRNA interrelated epithelial mesenchymal transition (EMT) in glioblastoma

BP Setlai, R Hull, RM Reis, C Agbor, MA Ambele… - Genes, 2022 - mdpi.com
MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length,
functioning as regulators of oncogenes or tumor suppressor genes. They are molecular …

Mesenchymal transformation: the rosetta stone of glioblastoma pathogenesis and therapy resistance

Z Azam, SST TO, BA Tannous - Advanced science, 2020 - Wiley Online Library
Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms
of cancers. The high level of inter‐and intratumoral heterogeneity along with its biological …

[HTML][HTML] PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma

E Yang, L Wang, W Jin, X Liu, Q Wang, Y Wu, Y Tan… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The concentration and duration of intracellular drugs have always been the key
factors for determining the efficacy of the treatment. Efflux of chemotherapeutic drugs or …

Current insights on extracellular vesicle-mediated glioblastoma progression: Implications in drug resistance and epithelial-mesenchymal transition

S Mukherjee, PP Pillai - Biochimica et Biophysica Acta (BBA)-General …, 2022 - Elsevier
Background Glioblastoma multiforme (GBM) is one of the most fatal tumors of the central
nervous system with high rate of disease progression, diagnosis, prognosis and low survival …

Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play

J Erbani, M Boon, L Akkari - Seminars in Cancer Biology, 2022 - Elsevier
The intricate cross-talks between tumor cells and their microenvironment play a key role in
cancer progression and resistance to treatment. In recent years, targeting pro-tumorigenic …

Role of tumor-derived extracellular vesicles in glioblastoma

Y Chen, Y Jin, N Wu - Cells, 2021 - mdpi.com
Glioblastoma (GBM) is the most common primary central nervous system tumor and one of
the most lethal cancers worldwide, with morbidity of 5.26 per 100,000 population per year …

The multifaceted role of extracellular vesicles in glioblastoma: microRNA nanocarriers for disease progression and gene therapy

N Simionescu, R Zonda, AR Petrovici, A Georgescu - Pharmaceutics, 2021 - mdpi.com
Glioblastoma (GB) is the most aggressive form of brain cancer in adults, characterized by
poor survival rates and lack of effective therapies. MicroRNAs (miRNAs) are small, non …