[HTML][HTML] Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

GL Hold, M Smith, C Grange, ER Watt… - World journal of …, 2014 - ncbi.nlm.nih.gov
Our understanding of the microbial involvement in inflammatory bowel disease (IBD)
pathogenesis has increased exponentially over the past decade. The development of newer …

Advances and perspectives in in vitro human gut fermentation modeling

AN Payne, A Zihler, C Chassard, C Lacroix - Trends in biotechnology, 2012 - cell.com
The gut microbiota is a highly specialized organ containing host-specific assemblages of
microbes whereby metabolic activity directly impacts human health and disease. In vitro gut …

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

MEV Johansson, JK Gustafsson, J Holmén-Larsson… - Gut, 2014 - gut.bmj.com
Objective The inner mucus layer in mouse colon normally separates bacteria from the
epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer …

Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis

C Hernández-Chirlaque, CJ Aranda… - Journal of Crohn's …, 2016 - academic.oup.com
Abstract Background and Aims: Intestinal microbiota is required to maintain immune
homeostasis and intestinal barrier function. At the same time, intraluminal bacteria are …

Current and emerging drugs for the treatment of inflammatory bowel disease

JK Triantafillidis, E Merikas… - … design, development and …, 2011 - Taylor & Francis
During the last decade a large number of biological agents against tumor necrosis factor-α
(TNF-α), as well as many biochemical substances and molecules specifically for the medical …

Dysbiosis in intestinal inflammation: cause or consequence

LF Buttó, D Haller - International Journal of Medical Microbiology, 2016 - Elsevier
The intestinal microbiota encompasses hundreds of bacterial species that constitute a
relatively stable ecosystem. Alteration in the microbiota composition may arise from …

[HTML][HTML] The immunological basis of inflammatory bowel disease

FAR Silva, BL Rodrigues, MLS Ayrizono… - … research and practice, 2016 - hindawi.com
Inflammatory bowel diseases (IBDs) are chronic ailments, Crohn's disease and ulcerative
colitis being the most important. These diseases present an inflammatory profile and they …

Opportunities and challenges of whole-genome and-exome sequencing

BS Petersen, B Fredrich, MP Hoeppner, D Ellinghaus… - BMC genetics, 2017 - Springer
Recent advances in the development of sequencing technologies provide researchers with
unprecedented possibilities for genetic analyses. In this review, we will discuss the history of …

Human gut microbiota: toward an ecology of disease

S Selber-Hnatiw, B Rukundo, M Ahmadi… - Frontiers in …, 2017 - frontiersin.org
Composed of trillions of individual microbes, the human gut microbiota has adapted to the
uniquely diverse environments found in the human intestine. Quickly responding to the …

The role of the gut microbiota in the treatment of inflammatory bowel diseases

I Aggeletopoulou, C Konstantakis… - Microbial …, 2019 - Elsevier
The human intestinal microbiota coevolves with its host through a symbiotic relationship and
exerts great influence on substantial functions including aspects of physiology, metabolism …