Computational studies of lipid droplets
Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage.
Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure …
Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure …
Application of computational approaches in biomembranes: From structure to function
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
Lessons for Oral bioavailability: how Conformationally flexible cyclic peptides enter and cross lipid membranes
Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-
bonding capacity. However, these properties impact also their passive membrane …
bonding capacity. However, these properties impact also their passive membrane …
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion.
Emerging evidence suggests that a direct yet unresolved interaction of the …
Emerging evidence suggests that a direct yet unresolved interaction of the …
Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface
P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …
behavior. Better understanding may evolve current drug delivery methods toward effective …
Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens
ML Heymich, U Friedlein, M Trollmann, K Schwaiger… - Food chemistry, 2021 - Elsevier
Contamination with bacteria leads to food waste and foodborne diseases with severe
consequences for the environment and human health. Aiming to reduce food spoilage and …
consequences for the environment and human health. Aiming to reduce food spoilage and …
GROmaρs: A GROMACS-based toolset to analyze density maps derived from molecular dynamics simulations
We introduce a computational toolset, named GROmaρs, to obtain and compare time-
averaged density maps from molecular dynamics simulations. GROmaρs efficiently …
averaged density maps from molecular dynamics simulations. GROmaρs efficiently …
MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Biological membranes have a stunning ability to adapt their composition in response to
physiological stress and metabolic challenges. Little is known how such perturbations affect …
physiological stress and metabolic challenges. Little is known how such perturbations affect …
Structure and dynamics of the acyl chains in the membrane trafficking and enzymatic processing of lipids
Conspectus The regulatory chemical mechanisms of lipid trafficking and degradation are
involved in many pathophysiological processes, being implicated in severe pain …
involved in many pathophysiological processes, being implicated in severe pain …