Non-lysine ubiquitylation: Doing things differently

IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …

Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders

Y Fujiki, K Okumoto, M Honsho, Y Abe - Biochimica et Biophysica Acta …, 2022 - Elsevier
Peroxisomes are single-membrane organelles essential for cell metabolism including the β-
oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis …

PEX5 translocation into and out of peroxisomes drives matrix protein import

ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

The peroxisome: an update on mysteries

M Islinger, S Grille, HD Fahimi, M Schrader - Histochemistry and cell …, 2012 - Springer
Peroxisomes contribute to several crucial metabolic processes such as β-oxidation of fatty
acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species …

Peroxisome biogenesis in mammalian cells

Y Fujiki, K Okumoto, S Mukai, M Honsho… - Frontiers in …, 2014 - frontiersin.org
To investigate peroxisome assembly and human peroxisome biogenesis disorders (PBDs)
such as Zellweger syndrome, thirteen different complementation groups (CGs) of Chinese …

ATP-Dependent Steps in Peroxisomal Protein Import

HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

[HTML][HTML] Protein import machineries of peroxisomes

R Rucktäschel, W Girzalsky, R Erdmann - Biochimica et Biophysica Acta …, 2011 - Elsevier
Peroxisomes are a class of structurally and functionally related organelles present in almost
all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe …

Peroxisome: metabolic functions and biogenesis

K Okumoto, S Tamura, M Honsho, Y Fujiki - … Biology: Experimental Models …, 2020 - Springer
Peroxisome is an organelle conserved in almost all eukaryotic cells with a variety of
functions in cellular metabolism, including fatty acid β-oxidation, synthesis of ether …

[HTML][HTML] The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress

PA Walton, C Brees, C Lismont, O Apanasets… - … Et Biophysica Acta (BBA …, 2017 - Elsevier
Accumulating evidence indicates that peroxisome functioning, catalase localization, and
cellular oxidative balance are intimately interconnected. Nevertheless, it remains largely …

Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate

CP Grou, T Francisco, TA Rodrigues, MO Freitas… - Journal of Biological …, 2012 - ASBMB
Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized
peroxisomal matrix proteins in the cytosol and promotes their translocation across the …