The osteocyte as a signaling cell

J Delgado-Calle, T Bellido - Physiological reviews, 2022 - journals.physiology.org
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Osteocytes and skeletal pathophysiology

J Delgado-Calle, T Bellido - Current molecular biology reports, 2015 - Springer
For many years, osteocytes have been the forgotten bone cells and considered as inactive
spectators buried in the bone matrix. We now know that osteocytes detect and respond to …

A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing

K Paek, S Kim, S Tak, MK Kim, J Park… - Bioengineering & …, 2023 - Wiley Online Library
Although numerous organ‐on‐a‐chips have been developed, bone‐on‐a‐chip platforms
have rarely been reported because of the high complexity of the bone microenvironment …

Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated‐M1 Macrophage Polarization‐Dependent Vascular Smooth Muscle …

Y Xing, S Pan, L Zhu, Q Cui, Z Tang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Objective. The objective of this study was to investigate the involved mechanisms of
advanced glycation end product‐(AGE‐) exacerbated atherosclerosis (AS). Methods. Toll …

Reduction of SOST gene promotes bone formation through the Wnt/β‐catenin signalling pathway and compensates particle‐induced osteolysis

ZH Zhang, XY Jia, JY Fang, H Chai… - Journal of Cellular …, 2020 - Wiley Online Library
The increase in bone resorption and/or the inhibition of bone regeneration caused by wear
particles are the main causes of periprosthetic osteolysis. The SOST gene and Sclerostin, a …

miR‐219a‐5p Regulates Rorβ During Osteoblast Differentiation and in Age‐related Bone Loss

R Aquino‐Martinez, JN Farr… - Journal of Bone and …, 2019 - academic.oup.com
Developing novel approaches to treat skeletal disorders requires an understanding of how
critical molecular factors regulate osteoblast differentiation and bone remodeling. We have …

Connexin43 and Runx2 interact to affect cortical bone geometry, skeletal development, and osteoblast and osteoclast function

AM Buo, RE Tomlinson, ER Eidelman… - Journal of Bone and …, 2017 - academic.oup.com
The coupling of osteoblasts and osteocytes by connexin43 (Cx43) gap junctions permits the
sharing of second messengers that coordinate bone cell function and cortical bone …

Connexins and pannexins in the skeleton: gap junctions, hemichannels and more

LI Plotkin, JP Stains - Cellular and molecular life sciences, 2015 - Springer
Regulation of bone homeostasis depends on the concerted actions of bone-forming
osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from …

IDG-SW3 osteocyte differentiation and bone extracellular matrix deposition are enhanced in a 3D matrix metalloproteinase-sensitive hydrogel

AH Aziz, RL Wilmoth, VL Ferguson… - ACS applied bio …, 2020 - ACS Publications
Osteocytes reside within a heavily mineralized matrix, making them difficult to study in vivo
and to extract for studies in vitro. IDG-SW3 cells are capable of producing a mineralized …

MicroRNA  19a  3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence

J Kaur, D Saul, ML Doolittle, JN Farr… - Journal of Bone and …, 2023 - academic.oup.com
Aging is a major risk factor for most chronic diseases, including osteoporosis, and is
characterized by an accumulation of senescent cells in various tissues. MicroRNAs …