The osteocyte as a signaling cell
J Delgado-Calle, T Bellido - Physiological reviews, 2022 - journals.physiology.org
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
Osteocytes and skeletal pathophysiology
J Delgado-Calle, T Bellido - Current molecular biology reports, 2015 - Springer
For many years, osteocytes have been the forgotten bone cells and considered as inactive
spectators buried in the bone matrix. We now know that osteocytes detect and respond to …
spectators buried in the bone matrix. We now know that osteocytes detect and respond to …
A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing
Although numerous organ‐on‐a‐chips have been developed, bone‐on‐a‐chip platforms
have rarely been reported because of the high complexity of the bone microenvironment …
have rarely been reported because of the high complexity of the bone microenvironment …
Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated‐M1 Macrophage Polarization‐Dependent Vascular Smooth Muscle …
Y Xing, S Pan, L Zhu, Q Cui, Z Tang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Objective. The objective of this study was to investigate the involved mechanisms of
advanced glycation end product‐(AGE‐) exacerbated atherosclerosis (AS). Methods. Toll …
advanced glycation end product‐(AGE‐) exacerbated atherosclerosis (AS). Methods. Toll …
Reduction of SOST gene promotes bone formation through the Wnt/β‐catenin signalling pathway and compensates particle‐induced osteolysis
ZH Zhang, XY Jia, JY Fang, H Chai… - Journal of Cellular …, 2020 - Wiley Online Library
The increase in bone resorption and/or the inhibition of bone regeneration caused by wear
particles are the main causes of periprosthetic osteolysis. The SOST gene and Sclerostin, a …
particles are the main causes of periprosthetic osteolysis. The SOST gene and Sclerostin, a …
miR‐219a‐5p Regulates Rorβ During Osteoblast Differentiation and in Age‐related Bone Loss
R Aquino‐Martinez, JN Farr… - Journal of Bone and …, 2019 - academic.oup.com
Developing novel approaches to treat skeletal disorders requires an understanding of how
critical molecular factors regulate osteoblast differentiation and bone remodeling. We have …
critical molecular factors regulate osteoblast differentiation and bone remodeling. We have …
Connexin43 and Runx2 interact to affect cortical bone geometry, skeletal development, and osteoblast and osteoclast function
AM Buo, RE Tomlinson, ER Eidelman… - Journal of Bone and …, 2017 - academic.oup.com
The coupling of osteoblasts and osteocytes by connexin43 (Cx43) gap junctions permits the
sharing of second messengers that coordinate bone cell function and cortical bone …
sharing of second messengers that coordinate bone cell function and cortical bone …
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more
LI Plotkin, JP Stains - Cellular and molecular life sciences, 2015 - Springer
Regulation of bone homeostasis depends on the concerted actions of bone-forming
osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from …
osteoblasts and bone-resorbing osteoclasts, controlled by osteocytes, cells derived from …
IDG-SW3 osteocyte differentiation and bone extracellular matrix deposition are enhanced in a 3D matrix metalloproteinase-sensitive hydrogel
Osteocytes reside within a heavily mineralized matrix, making them difficult to study in vivo
and to extract for studies in vitro. IDG-SW3 cells are capable of producing a mineralized …
and to extract for studies in vitro. IDG-SW3 cells are capable of producing a mineralized …
MicroRNA 19a 3p Decreases with Age in Mice and Humans and Inhibits Osteoblast Senescence
Aging is a major risk factor for most chronic diseases, including osteoporosis, and is
characterized by an accumulation of senescent cells in various tissues. MicroRNAs …
characterized by an accumulation of senescent cells in various tissues. MicroRNAs …