Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Although the combined antiretroviral therapy (cART) has decreased the deaths associated
with the immune deficiency acquired syndrome (AIDS), non-AIDS conditions have emerged …

Follicular CD8+ T cells (fCD8) mediate surveillance in lymph node (LN) germinal centers
against lymphotropic infections and cancers, but the precise mechanisms by which these …

One reason underlying the failure of current chimeric antigen receptor (CAR) immune
therapy to treat solid tumors adequately is insufficient tumor infiltration of CAR immune cells …

HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to
functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV …

Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an
epidemic disease that has killed millions of people in the last several decades. Although …

CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune
clearance of infected and cancerous cells and provide long-term protection. Recent …

T cells are known as the most potent killer cells of the immune system, designed by nature to
prevent unwanted challenges. The first class of therapeutic products harnessing the power …

Ex vivo expansion of T lymphocytes is a central process in the generation of cellular
therapies targeted at tumors and other disease-relevant structures, which currently cannot …

The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a
therapeutic cure for HIV. Several strategies have been developed to purge the reservoir …