An increasing evidence suggests that vanadium compounds are novel potential drugs in the
treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated …

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …

JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in
treating complex diseases such as cancers and immune-mediated disorders. However, their …

Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal
transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Cytokines of the IL-12 family show structural similarities but have distinct functions in the
immune system. Prominent members of this cytokine family are the pro-inflammatory …

The discovery of JAKs and STATs and their roles in cytokine and IFN action represented a
significant basic advance and a new paradigm in cell signaling. This was quickly followed by …

In this review we concentrate on the recent findings describing the oncogenic potential of the
protein tyrosine kinase 2 (TYK2). The overview on the current understanding of TYK2 …

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in
mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 …

Genetic variants associated with susceptibility to autoimmune disease have provided
important insight into the mechanisms responsible for the loss of immune tolerance and the …