[HTML][HTML] The downregulation of opioid receptors and neuropathic pain
L Li, J Chen, YQ Li - International Journal of Molecular Sciences, 2023 - mdpi.com
Neuropathic pain (NP) refers to pain caused by primary or secondary damage or dysfunction
of the peripheral or central nervous system, which seriously affects the physical and mental …
of the peripheral or central nervous system, which seriously affects the physical and mental …
Endogenous opiates and behavior: 2016
RJ Bodnar - Peptides, 2018 - Elsevier
This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …
concerning the endogenous opioid system. It summarizes papers published during 2016 …
N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …
Downregulation of a dorsal root ganglion‐specifically enriched long noncoding RNA is required for neuropathic pain by negatively regulating RALY‐triggered Ehmt2 …
Nerve injury‐induced maladaptive changes of gene expression in dorsal root ganglion
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …
(DRG) neurons contribute to neuropathic pain. Long non‐coding RNAs (lncRNAs) are …
Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons
Expressional changes of pain-associated genes in primary sensory neurons of DRG are
critical for neuropathic pain genesis. DNA methyltransferase (DNMT)-triggered DNA …
critical for neuropathic pain genesis. DNA methyltransferase (DNMT)-triggered DNA …
Nerve injury–induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons
Opioids are the gold standard for pharmacological treatment of neuropathic pain, but their
analgesic effects are unsatisfactory in part due to nerve injury–induced downregulation of …
analgesic effects are unsatisfactory in part due to nerve injury–induced downregulation of …
[HTML][HTML] Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons
Abstract Toll like receptor 7 (TLR7) is expressed in neurons of the dorsal root ganglion
(DRG), but whether it contributes to neuropathic pain is elusive. We found that peripheral …
(DRG), but whether it contributes to neuropathic pain is elusive. We found that peripheral …
The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity
Changes in gene transcription in the dorsal root ganglion (DRG) after nerve trauma
contribute to the genesis of neuropathic pain. We report that peripheral nerve trauma caused …
contribute to the genesis of neuropathic pain. We report that peripheral nerve trauma caused …
MBD1 contributes to the genesis of acute pain and neuropathic pain by epigenetic silencing of Oprm1 and Kcna2 genes in primary sensory neurons
The transmission of normal sensory and/or acute noxious information requires intact
expression of pain-associated genes within the pain pathways of nervous system …
expression of pain-associated genes within the pain pathways of nervous system …
[HTML][HTML] MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions
N Sun, L Yu, Y Gao, L Ma, J Ren, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Opioids are the last option for the pharmacological treatment of neuropathic pain, but their
antinociceptive effects are limited. Decreased mu opioid receptor (MOR) expression in the …
antinociceptive effects are limited. Decreased mu opioid receptor (MOR) expression in the …