Prognostic and predictive enrichment in sepsis
NL Stanski, HR Wong - Nature Reviews Nephrology, 2020 - nature.com
Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …
Gene expression profiling in sepsis: timing, tissue, and translational considerations
DM Maslove, HR Wong - Trends in molecular medicine, 2014 - cell.com
Sepsis is a complex inflammatory response to infection. Microarray-based gene expression
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …
An integrated clinico-metabolomic model improves prediction of death in sepsis
RJ Langley, EL Tsalik, JC Velkinburgh… - Science translational …, 2013 - science.org
Sepsis is a common cause of death, but outcomes in individual patients are difficult to
predict. Elucidating the molecular processes that differ between sepsis patients who survive …
predict. Elucidating the molecular processes that differ between sepsis patients who survive …
Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies
MT Patrick, H Zhang, R Wasikowski, EP Prens… - Journal of Allergy and …, 2021 - Elsevier
Background Coronavirus disease 2019 (COVID-19) is commonly associated with skin
manifestations, and may also exacerbate existing skin diseases, yet the relationship …
manifestations, and may also exacerbate existing skin diseases, yet the relationship …
Acute respiratory distress syndrome neutrophils have a distinct phenotype and are resistant to phosphoinositide 3-kinase inhibition
JK Juss, D House, A Amour, M Begg… - American journal of …, 2016 - atsjournals.org
Rationale: Acute respiratory distress syndrome is refractory to pharmacological intervention.
Inappropriate activation of alveolar neutrophils is believed to underpin this disease's …
Inappropriate activation of alveolar neutrophils is believed to underpin this disease's …
Discovery and validation of new potential biomarkers for early detection of colon cancer
Background Accurate detection of characteristic proteins secreted by colon cancer tumor
cells in biological fluids could serve as a biomarker for the disease. The aim of the present …
cells in biological fluids could serve as a biomarker for the disease. The aim of the present …
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients
AG Cuenca, LF Gentile, MC Lopez, R Ungaro… - Critical care …, 2013 - journals.lww.com
Objective: Many patients have complicated recoveries following severe trauma due to the
development of organ injury. Physiological and anatomical prognosticators have had limited …
development of organ injury. Physiological and anatomical prognosticators have had limited …
Genomics of injury: the Glue Grant experience
RG Tompkins - Journal of trauma and acute care surgery, 2015 - journals.lww.com
Multiple technologies and knowledge bases including human genome sequence, 1
microarrays, 2 and human HapMaps 3 became available beginning in the late 1990s, and …
microarrays, 2 and human HapMaps 3 became available beginning in the late 1990s, and …
Revealing insect herbivory‐induced phenolamide metabolism: from single genes to metabolic network plasticity analysis
E Gaquerel, J Gulati, IT Baldwin - The Plant Journal, 2014 - Wiley Online Library
The phenylpropanoid metabolic space comprises a network of interconnected metabolic
branches that contribute to the biosynthesis of a large array of compounds with functions in …
branches that contribute to the biosynthesis of a large array of compounds with functions in …
Temporal dynamics of the transcriptional response to dengue virus infection in Nicaraguan children
Dengue is the most prevalent mosquito-borne human illness worldwide. The ability to
predict disease severity during the earliest days of the illness is a long-sought, but …
predict disease severity during the earliest days of the illness is a long-sought, but …