Prognostic and predictive enrichment in sepsis

NL Stanski, HR Wong - Nature Reviews Nephrology, 2020 - nature.com
Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Gene expression profiling in sepsis: timing, tissue, and translational considerations

DM Maslove, HR Wong - Trends in molecular medicine, 2014 - cell.com
Sepsis is a complex inflammatory response to infection. Microarray-based gene expression
studies of sepsis have illuminated the complex pathogen recognition and inflammatory …

An integrated clinico-metabolomic model improves prediction of death in sepsis

RJ Langley, EL Tsalik, JC Velkinburgh… - Science translational …, 2013 - science.org
Sepsis is a common cause of death, but outcomes in individual patients are difficult to
predict. Elucidating the molecular processes that differ between sepsis patients who survive …

Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies

MT Patrick, H Zhang, R Wasikowski, EP Prens… - Journal of Allergy and …, 2021 - Elsevier
Background Coronavirus disease 2019 (COVID-19) is commonly associated with skin
manifestations, and may also exacerbate existing skin diseases, yet the relationship …

Acute respiratory distress syndrome neutrophils have a distinct phenotype and are resistant to phosphoinositide 3-kinase inhibition

JK Juss, D House, A Amour, M Begg… - American journal of …, 2016 - atsjournals.org
Rationale: Acute respiratory distress syndrome is refractory to pharmacological intervention.
Inappropriate activation of alveolar neutrophils is believed to underpin this disease's …

Discovery and validation of new potential biomarkers for early detection of colon cancer

X Solé, M Crous-Bou, D Cordero, D Olivares, E Guinó… - PLoS …, 2014 - journals.plos.org
Background Accurate detection of characteristic proteins secreted by colon cancer tumor
cells in biological fluids could serve as a biomarker for the disease. The aim of the present …

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients

AG Cuenca, LF Gentile, MC Lopez, R Ungaro… - Critical care …, 2013 - journals.lww.com
Objective: Many patients have complicated recoveries following severe trauma due to the
development of organ injury. Physiological and anatomical prognosticators have had limited …

Genomics of injury: the Glue Grant experience

RG Tompkins - Journal of trauma and acute care surgery, 2015 - journals.lww.com
Multiple technologies and knowledge bases including human genome sequence, 1
microarrays, 2 and human HapMaps 3 became available beginning in the late 1990s, and …

Revealing insect herbivory‐induced phenolamide metabolism: from single genes to metabolic network plasticity analysis

E Gaquerel, J Gulati, IT Baldwin - The Plant Journal, 2014 - Wiley Online Library
The phenylpropanoid metabolic space comprises a network of interconnected metabolic
branches that contribute to the biosynthesis of a large array of compounds with functions in …

Temporal dynamics of the transcriptional response to dengue virus infection in Nicaraguan children

SJ Popper, A Gordon, M Liu, A Balmaseda… - PLoS neglected …, 2012 - journals.plos.org
Dengue is the most prevalent mosquito-borne human illness worldwide. The ability to
predict disease severity during the earliest days of the illness is a long-sought, but …