Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

Osteoblast cell adhesion is the initial step of early osseointegration responding to bone
material implants. Enhancing the osteoblastic cell adhesion has become one of the prime …

The bone morphogenetic protein (BMP) and Wnt signaling pathways both contribute
essential roles in regulating bone mass. However, the molecular interactions between these …

Mechanical loading of bone is important for maintenance of bone mass and structural
stability of the skeleton. When bone is mechanically loaded, movement of fluid within the …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …

Leiomyoma are common tumors arising within the uterus that feature excessive deposition
of a stiff, disordered extracellular matrix (ECM). Mechanical stress is a critical determinant of …

Load-induced fluid flow acts as an important biophysical signal for bone cell
mechanotransduction in vivo, where the mechanical environment is thought to be monitored …

Mechanical stimuli can improve bone function by promoting the proliferation and
differentiation of bone cells and osteoblasts. As precursors of osteoblasts, human …