Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …

Numerous cellular processes require the concerted action of multiple proteins that assemble
in functional complexes. Protein-protein interaction domains allow specific proteins to …

The control of target gene expression by nuclear receptors requires the recruitment of
multiple cofactors. However, the exact mechanisms by which nuclear receptor–cofactor …

During sarcomere contraction skeletal and cardiac muscle cells consume large amounts of
energy. To satisfy this demand, metabolic enzymes are associated with distinct regions of …

Transcription factors of the CREB family control the expression of a large number of genes in
response to various signaling pathways. Regulation mediated by members of the CREB …

The androgen receptor (AR) activation function 2 region of the ligand binding domain binds
the LXXLL motifs of p160 coactivators weakly, engaging instead in an androgen-dependent …

LIM domain containing proteins play critical roles in animal development and cellular
differentiation. Here, we describe the cloning and expression patterns of three members of …

Background—A deficiency of muscle LIM protein results in dilated cardiomyopathy, but the
function of other LIM proteins in the heart has not been assessed previously. We have …

GTPases of the Rho family are transducers of extracellular signals and control cellular
processes such as organization of the actin cytoskeleton, motility, adhesion and gene …