Hypertension, diabetes, atherosclerosis and NASH: cause or consequence?

A Lonardo, F Nascimbeni, A Mantovani, G Targher - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most common forms of
chronic liver disease worldwide and its prevalence is expected to continue rising. NAFLD …

[HTML][HTML] Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome

A Lonardo, S Ballestri, G Marchesini, P Angulo… - Digestive and Liver …, 2015 - Elsevier
The conventional paradigm of nonalcoholic fatty liver disease representing the “hepatic
manifestation of the metabolic syndrome” is outdated. We identified and summarized …

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

A Lonardo, S Bellentani, CK Argo, S Ballestri… - Digestive and Liver …, 2015 - Elsevier
An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to
identification of individuals at high risk of developing chronic liver disease and extra-hepatic …

[HTML][HTML] The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of …

SC Shabalala, PV Dludla, L Mabasa, AP Kappo… - Biomedicine & …, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications

K Cusi - Gastroenterology, 2012 - Elsevier
As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is
becoming a frequent cause of patient referral to gastroenterologists. There is a close link …

[PDF][PDF] Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites

BA Neuschwander‐Tetri - Hepatology, 2010 - Wiley Online Library
With nonalcoholic steatohepatitis (NASH), NASH cirrhosis, and NASH-related hepatocellular
carcinoma becoming increasingly prevalent, the need for effective therapies has never been …

Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease

SA Harrison, D Oliver, HL Arnold, S Gogia… - Gut, 2008 - gut.bmj.com
Background: Clinical predictors of advanced non-alcoholic liver disease (NAFLD) are
needed to guide diagnostic evaluation and treatment. Methods: To better understand the …

Overproduction of very low–density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

M Adiels, SO Olofsson, MR Taskinen… - … , and vascular biology, 2008 - Am Heart Assoc
Insulin resistance is a key feature of the metabolic syndrome and often progresses to type 2
diabetes. Both insulin resistance and type 2 diabetes are characterized by dyslipidemia …

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

M Ricchi, MR Odoardi, L Carulli… - Journal of …, 2009 - Wiley Online Library
Abstract Background and Aim: Studies have shown monounsaturated oleic acid to be less
toxic than palmitic acid and to prevent/attenuate palmitic acid hepatocites toxicity in steatosis …

Non-alcoholic fatty liver disease and risk of cardiovascular disease

A Lonardo, S Sookoian, CJ Pirola, G Targher - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver
diseases worldwide, causing considerable liver-related mortality and morbidity. During the …