Vitamin B6: a long known compound of surprising complexity

S Mooney, JE Leuendorf, C Hendrickson, H Hellmann - Molecules, 2009 - mdpi.com
In recent years vitamin B6 has become a focus of research describing the compound's
critical function in cellular metabolism and stress response. For many years the sole function …

Vitamin B6: A Molecule for Human Health?

H Hellmann, S Mooney - Molecules, 2010 - mdpi.com
Vitamin B6 is an intriguing molecule that is involved in a wide range of metabolic,
physiological and developmental processes. Based on its water solubility and high reactivity …

Two independent routes of de novo vitamin B6 biosynthesis: not that different after all

TB Fitzpatrick, N Amrhein, B Kappes… - Biochemical …, 2007 - portlandpress.com
Vitamin B6 is well known in its biochemically active form as pyridoxal 5′-phosphate, an
essential cofactor of numerous metabolic enzymes. The vitamin is also implicated in …

PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis

O Titiz, M Tambasco‐Studart, E Warzych… - The Plant …, 2006 - Wiley Online Library
Vitamin B6 is an essential coenzyme for numerous metabolic enzymes and is a potent
antioxidant. In plants, very little is known about its contribution to viability, growth and …

Pyridoxal phosphate: biosynthesis and catabolism

T Mukherjee, J Hanes, I Tews, SE Ealick… - Biochimica et Biophysica …, 2011 - Elsevier
Vitamin B6 is an essential cofactor that participates in a large number of biochemical
reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the …

Elucidating biosynthetic pathways for vitamins and cofactors

ME Webb, A Marquet, RR Mendel, F Rébeillé… - Natural product …, 2007 - pubs.rsc.org
Covering: up to 2007 The elucidation of the pathways to the water-soluble vitamins and
cofactors has provided many biochemical and chemical challenges. This is a reflection both …

Ginkgo biloba and Ginkgotoxin

E Leistner, C Drewke - Journal of natural products, 2010 - ACS Publications
Products prepared from Ginkgo biloba are top-selling phytopharmaceuticals especially in
Europe and major botanical dietary supplements in the United States. In European …

Structure of a bacterial pyridoxal 5′-phosphate synthase complex

M Strohmeier, T Raschle… - Proceedings of the …, 2006 - National Acad Sciences
Vitamin B6 is an essential metabolic cofactor that has more functions in humans than any
other single nutrient. Its de novo biosynthesis occurs through two mutually exclusive …

Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis

T Dick, U Manjunatha, B Kappes… - Molecular …, 2010 - Wiley Online Library
With 500 000 cases of multidrug‐resistant tuberculosis there is an urgent need for attractive
targets to enable the discovery of novel antimycobacterials. The biosynthesis of essential …

Fragment-based screening of a natural product library against 62 potential malaria drug targets employing native mass spectrometry

H Vu, L Pedro, T Mak, B McCormick… - ACS infectious …, 2018 - ACS Publications
Natural products are well known for their biological relevance, high degree of three-
dimensionality, and access to areas of largely unexplored chemical space. To shape our …