Investigators acknowledge the limitations of rodent or non-human primate stroke models,
hundreds of putative neuroprotectants have been evaluated in preclinical models, but not …

Acute ischaemic stroke accounts for 6.5 million deaths per year, and by 2030 will result in
the annual loss of over 200 million disability-adjusted life years globally. There have been …

Background The optimum systolic blood pressure after endovascular thrombectomy for
acute ischaemic stroke is uncertain. We aimed to compare the safety and efficacy of blood …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Human diseases may be modeled in animals to allow preclinical assessment of putative
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …

Stroke seriously threatens human health because of its characteristics of high morbidity,
disability, recurrence, and mortality, thus representing a heavy financial and mental burden …

3300 Stroke November 2019 allow more realistic and precise testing of cell delivery
techniques including stereotaxic and intra-arterial cell administration and dose translation to …

Background and Purpose—In experimental models of ischemic stroke, abrupt reperfusion is
associated with secondary brain damages, responsible for up to 70% of the final lesion size …

Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the
ischemic territory but can also cause significant ischemia-reperfusion (IR) injury. Previous …

Over the past forty years, animal models of focal cerebral ischaemia have allowed us to
identify the critical cerebral blood flow thresholds responsible for irreversible cell death …