Macrophages have a central role in numerous physiological processes, such as immune
defense, maintenance of tissue homeostasis, wound healing, and inflammation. Moreover …

Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation
and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat …

Tumor-associated myeloid cells (TAMCs) are among the most important immune cell
populations in the tumor microenvironment, and play a significant role on the efficacy of …

Neutrophils are key pathogen exterminators of the innate immune system endowed with
oxidative and non-oxidative defense mechanisms. More recently, a more complex role for …

Neutrophils, the most abundant circulating leukocytes in human, play an indispensable role
in the innate immune response to microbial infections. However, the contribution of tumor …

Granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil
trafficking and is highly expressed in multiple tumors. Myeloid derived suppressor cells …

Macrophage polarization is a highly plastic physiological process that responds to a variety
of environmental factors by changing macrophage phenotype and function. Tumor …

Colorectal cancer (CRC) development and progression is associated with chronic
inflammation. We have identified the MAPK‐activated protein kinase 2 (MK2) pathway as a …

Macrophages (MΦs) are an important immune cell population that are essential for tissue
homeostasis and disease pathogenesis. MΦs are now classified as either M1, which …

Numerous preclinical studies have reported a pro-tumour role for granulocyte colony-
stimulating factor (G-CSF) that is predominantly mediated by neutrophils and MDSCs, the …