Studies on the physiological functions of the melanocortin system
RD Cone - Endocrine reviews, 2006 - academic.oup.com
The melanocortin system refers to a set of hormonal, neuropeptidergic, and paracrine
signaling pathways that are defined by components that include the five G protein-coupled …
signaling pathways that are defined by components that include the five G protein-coupled …
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
BM King - Physiology & behavior, 2006 - Elsevier
Early researchers found that lesions of the ventromedial hypothalamus (VMH) resulted in
hyperphagia and obesity in a variety of species including humans, which led them to …
hyperphagia and obesity in a variety of species including humans, which led them to …
Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women
AB Loucks, JR Thuma - The Journal of Clinical Endocrinology & …, 2003 - academic.oup.com
To investigate the dependence of LH pulsatility on energy availability (dietary energy intake
minus exercise energy expenditure), we measured LH pulsatility after manipulating the …
minus exercise energy expenditure), we measured LH pulsatility after manipulating the …
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
Brain-derived neurotrophic factor has been associated previously with the regulation of food
intake. To help elucidate the role of this neurotrophin in weight regulation, we have …
intake. To help elucidate the role of this neurotrophin in weight regulation, we have …
[HTML][HTML] A high-fat, ketogenic diet induces a unique metabolic state in mice
Ketogenic diets have been used as an approach to weight loss on the basis of the
theoretical advantage of a low-carbohydrate, high-fat diet. To evaluate the physiological and …
theoretical advantage of a low-carbohydrate, high-fat diet. To evaluate the physiological and …
Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
J Kamegai, H Tamura, T Shimizu, S Ishii, H Sugihara… - Diabetes, 2001 - Am Diabetes Assoc
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R),
was originally purified from the rat stomach. Like the synthetic growth hormone …
was originally purified from the rat stomach. Like the synthetic growth hormone …
Leptin resistance and obesity
PJ Enriori, AE Evans, P Sinnayah, MA Cowley - Obesity, 2006 - Wiley Online Library
The prevalence of obesity, and the human and economic costs of the disease, creates a
need for better therapeutics and better understanding of the physiological processes that …
need for better therapeutics and better understanding of the physiological processes that …
Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein …
KA Takahashi, RD Cone - Endocrinology, 2005 - academic.oup.com
The neuropeptide Y (NPY)/Agouti-related protein (AgRP) neurons of the hypothalamic
arcuate nucleus are thought to promote feeding. Here, we demonstrate that feeding state in …
arcuate nucleus are thought to promote feeding. Here, we demonstrate that feeding state in …
Hypothalamic glucose sensing: making ends meet
VH Routh, L Hao, AM Santiago, Z Sheng… - Frontiers in systems …, 2014 - frontiersin.org
The neuroendocrine system governs essential survival and homeostatic functions. For
example, growth is needed for development, thermoregulation maintains optimal core …
example, growth is needed for development, thermoregulation maintains optimal core …
[PDF][PDF] Insulin and leptin as adiposity signals
There is now considerable consensus that the adipocyte hormone leptin and the pancreatic
hormone insulin are important regulators of food intake and energy balance. Leptin and …
hormone insulin are important regulators of food intake and energy balance. Leptin and …