Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism …

Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and its
contents are internalized into cells through large, heterogeneous vesicles known as …

Oncogenic KRAS mutation is the signature genetic event in the progression and growth of
pancreatic ductal adenocarcinoma (PDAC), an almost universally fatal disease. Although it …

Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

For a long time, apoptosis was considered the sole form of programmed cell death during
development, homeostasis and disease, whereas necrosis was regarded as an unregulated …

Abstract Since Otto Warburg reported the 'addiction'of cancer cells to fermentative glycolysis,
a metabolic pathway that provides energy and building blocks, thousands of studies have …

Besides fast glucose catabolism, many types of cancers are characterized by elevated
glutamine consumption. Medical oncology pursuits to block specific pathways, mainly …

In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1,
the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea …