Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
[HTML][HTML] N-linked protein glycosylation in the ER
M Aebi - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …
Mechanisms and principles of N-linked protein glycosylation
F Schwarz, M Aebi - Current opinion in structural biology, 2011 - Elsevier
N-linked glycosylation, a protein modification system present in all domains of life, is
characterized by a high structural diversity of N-linked glycans found among different …
characterized by a high structural diversity of N-linked glycans found among different …
N-linked protein glycosylation in the endoplasmic reticulum
J Breitling, M Aebi - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
The attachment of glycans to asparagine residues of proteins is an abundant and highly
conserved essential modification in eukaryotes. The N-glycosylation process includes two …
conserved essential modification in eukaryotes. The N-glycosylation process includes two …
X-ray structure of a bacterial oligosaccharyltransferase
C Lizak, S Gerber, S Numao, M Aebi, KP Locher - Nature, 2011 - nature.com
Asparagine-linked glycosylation is a post-translational modification of proteins containing
the conserved sequence motif Asn-X-Ser/Thr. The attachment of oligosaccharides is …
the conserved sequence motif Asn-X-Ser/Thr. The attachment of oligosaccharides is …
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
F Letourneur, EC Gaynor, S Hennecke, C Demolliere… - Cell, 1994 - cell.com
Dilysine motifs in cytoplasmic domains of transmembrane proteins are signals for their
continuous retrieval from the Golgi back to the endoplasmic reticulum (El?). We describe a …
continuous retrieval from the Golgi back to the endoplasmic reticulum (El?). We describe a …
Enzymes in the synthesis of glycoconjugates
RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylation
E Mohorko, R Glockshuber, M Aebi - Journal of inherited metabolic …, 2011 - Springer
N-linked glycosylation is one of the most abundant modifications of proteins in eukaryotic
organisms. In the central reaction of the pathway, oligosaccharyltransferase (OST), a …
organisms. In the central reaction of the pathway, oligosaccharyltransferase (OST), a …
N-linked glycosylation in Archaea: a structural, functional, and genetic analysis
SUMMARY N-glycosylation of proteins is one of the most prevalent posttranslational
modifications in nature. Accordingly, a pathway with shared commonalities is found in all …
modifications in nature. Accordingly, a pathway with shared commonalities is found in all …
Similarities and differences in the glycosylation mechanisms in prokaryotes and eukaryotes
Recent years have witnessed a rapid growth in the number and diversity of prokaryotic
proteins shown to carry N‐and/or O‐glycans, with protein glycosylation now considered as …
proteins shown to carry N‐and/or O‐glycans, with protein glycosylation now considered as …