Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …

Chemical biology strategies for directly perturbing protein homeostasis including the
degradation tag (dTAG) system provide temporal advantages over genetic approaches and …

Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …

Obesity increases the risk for cardiovascular diseases and induces cardiomyopathy. Chronic
inflammation plays a significant role in obesity-induced cardiomyopathy and may provide …

Lung adenocarcinoma is the most common form of lung cancer, accounting for 60% of non-
small cell lung cancer (NSCLC) cases in Asian patients. Importantly, nearly half of these …

Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates
worldwide. Doublecortin‐like kinase 1 (DCLK1), a microtubule‐associated protein kinase, is …

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in
human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is …