The complexity of tobacco smoke leads to some confusion about the mechanisms by which
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

Abstract Using the International Project on Genetic Susceptibility to Environmental
Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) …

Visualization and exploration of high-dimensional data is a ubiquitous challenge across
disciplines. Widely used techniques such as principal component analysis (PCA) aim to …

It is well recognized that most medications exhibit wide interpatient variability in their efficacy
and toxicity. For many medications, these interindividual differences are due in part to …

A common thread linking the main risks for developing breast cancer in women is
cumulative, excessive exposure to estrogen. The standard paradigm to account for this …

Carcinoma of the prostate is the most frequently diagnosed malignancy and the second
leading cause of death as a result of cancer in men in the United States and in many other …

The recent completion of the first draft of the human genome sequence and advances in
technologies for genomic analysis are generating tremendous opportunities for …

The harmful effects of oil on various species of flora and fauna have been studied
extensively; however, few studies have studied the effects of oil exposure on human health …

The human homologue of the yeast OGG1 gene, hOGG1, has been cloned, and its genetic
structure has been determined. Several polymorphisms in the hOGG1 gene were detected …