Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

H Chen, Y He, S Chen, S Qi, J Shen - Pharmacological Research, 2020 - Elsevier
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

[HTML][HTML] The effects of baicalin and baicalein on cerebral ischemia: a review

W Liang, X Huang, W Chen - Aging and disease, 2017 - ncbi.nlm.nih.gov
Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease.
Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin …

NSCs migration promoted and drug delivered exosomes‐collagen scaffold via a bio‐specific peptide for one‐step spinal cord injury repair

L Zhang, C Fan, W Hao, Y Zhuang, X Liu… - Advanced …, 2021 - Wiley Online Library
Spinal cord injury (SCI) is plaguing medical professionals globally due to the complexity of
injury progression. Based on tissue engineering technology, there recently emerges a …

[HTML][HTML] The neuroprotective effect of traditional Chinese medicinal plants—A critical review

J Moreira, M Machado, M Dias-Teixeira… - … Pharmaceutica Sinica B, 2023 - Elsevier
Neurodegenerative and neuropsychiatric diseases are increasingly affecting individuals'
quality of life, thus increasing their cost to social and health systems. These diseases have …

Neuroprotective and cognitive enhancement potentials of baicalin: a review

K Sowndhararajan, P Deepa, M Kim, SJ Park, S Kim - Brain Sciences, 2018 - mdpi.com
Neurodegenerative diseases are a heterogeneous group of disorders that are characterized
by the gradual loss of neurons. The development of effective neuroprotective agents to …

Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics

H Madhav, E Jameel, M Rehan, N Hoda - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

H Chen, X Chen, W Li, J Shen - Acta Pharmacologica Sinica, 2018 - nature.com
Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-
reperfusion injury. RNS activate multiple signaling pathways and participate in different …

Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer's disease model rats

J Zhao, S Lu, H Yu, S Duan, J Zhao - Brain research, 2018 - Elsevier
Background This study aimed to explore the effects of ginsenoside Rb1 and baicalin on the
proliferation and differentiation of neural stem cells (NSC) in Alzheimer's disease model rats …

The potential of plant extracts in cell therapy

C Li, Z Cui, S Deng, P Chen, X Li, H Yang - Stem Cell Research & Therapy, 2022 - Springer
Cell therapy is the frontier technology of biotechnology innovation and the most promising
method for the treatment of refractory diseases such as tumours. However, cell therapy has …

Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex

X Liu, C Liu - International immunopharmacology, 2017 - Elsevier
Abnormal activation of nucleotide-binding domain, leucine-rich repeat, pyrin domain
containing protein 3 (NLRP3) inflammasome could induce inflammation in the central …