Left ventricular hypertrophy (LVH) is the most common myocardial structural abnormality
associated with heart failure with preserved ejection fraction (HFpEF). LVH is driven by …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

Background Sodium–glucose linked transporter type 2 (SGLT-2) inhibition has been shown
to reduce cardiovascular mortality in heart failure independently of glycemic control and …

Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients
hospitalized with heart failure, HFpEF is now as common as heart failure with reduced …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key
mediators of mechanotransduction during both physiological adaptation to mechanical load …

Aging of the heart is associated with a blunted response to sympathetic stimulation, reduced
contractility, and increased propensity for arrhythmias, with the risk of sudden cardiac death …

BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …

Key points Heart failure (HF), the leading cause of death in developed countries, occurs in
the setting of reduced (HFrEF) or preserved (HFpEF) ejection fraction. Unlike HFrEF, there …