Ion mobility spectrometry (IMS) has become popular to characterize biomolecule folding.
Numerous studies have shown that proteins that are folded in solution remain folded in the …

We proposed and demonstrated a kinetically interlocking multiple-units supramolecular
polymerization strategy. Through rationally designed multiple-units monomers, the degree of …

Cytosine-rich DNA sequences fold into secondary structures called i-Motifs, which are
usually stable at acidic pH. However, molecular crowding agents, such as poly (ethylene …

Molecular dynamics simulations were employed to study the properties of G-quadruplex and
i-motif secondary DNA structures formed within the canonical telomere fragment of the …

There have been controversies about the binding of cations to poly (ethylene oxide)(PEO)
chains in aqueous solutions. In the current study, single molecular evidence of charging …

Charged macromolecules under flow are ubiquitous, and the important physics inside is not
yet well understood. In this study, single-molecule fluorescence spectroscopy methods are …

For the purpose of understanding the molecular origins of the rheological properties of
polyelectrolyte solutions, an in situ investigation into the distribution of counterions of a …

Switchable inversion of chirality between opposite handedness by varying pH is discovered
for a histidine pendant polymer, polymethyl (4-vinylbenzoyl) histidinate (PBHis), as …

It is well documented that conventional methods such as dynamic light scattering have
encountered difficulties in characterizing charged macromolecules and, therefore, it is …

In this work we studied the unfolding processes of the noncanonical telomeric DNA
fragments, ie G-quadruplex and i-motif. These transitions were analyzed in details by …