With an ageing population comes an inevitable increase in the prevalence of age-
associated neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), a …

Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing
disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately …

Tissue regeneration after injury requires coordinated regulation of stem cell activation,
division, and daughter cell differentiation, processes that are increasingly well understood in …

What is the nature of aging, and how best can we study it? Here, using a series of questions
that highlight differing perspectives about the nature of aging, we ask how data from …

Insects exhibit a remarkable ability to interact with inanimate objects to facilitate essential
behaviors such as foraging, reproduction, shelter building, and defense. In this study, we …

A fundamental question in cell biology is how cellular components are delivered to their
destination with spatial and temporal precision within the crowded cytoplasmic environment …

Cytoplasmic aggregation of T ar-D NA/RNA binding p rotein 43 (TDP-43) occurs in 97
percent of amyotrophic lateral sclerosis (ALS),~ 40% of frontotemporal dementia (FTD) and …

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative
condition that is invariably fatal, usually within 3 to 5 years of diagnosis. The etiology of ALS …

Most cellular processes descend into failure during aging. While a large collection of
longevity pathways has been identified in the past decades, the mechanism for age-related …

Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in several consumer
products. However, because of their neurotoxic nature, exposure to TiO 2 NPs could impair …